WebNational Center for Biotechnology Information WebThis motif is known to bind tetratricopeptide repeat (TPR) domain co-chaperones, such as the E3 ubiquitin ligase CHIP. In addition, the EEVD motif also interacts with a structurally distinct...
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WebSep 29, 2024 · CHIP N-terminal tetratricopeptide repeat domain. This is N-terminal tetratricopeptide repeat (TPR) domain found in C terminus of Hsp70 interacting proteins … WebThe yellow arrows indicate the hydrophobic pockets on CHIP-TPR accommodating Ile-461 and Val-464 of Smad1. In the right panel, CHIP-TPR is colored in slate, and the α-helices are labeled α1 to α7 from the N to C termini. B, shown is a schematic representation of CHIP-TPR (orange) in complex with pseudophosphorylated Smad1(DVD) peptide (yellow). in case you missed it emoji
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WebDec 16, 2024 · CHIP binds to Hsp70 and Hsp90 chaperones through its tetratricopeptide repeat (TPR) domain and functions as an E3 ubiquitin ligase using a modified RING finger domain (U-box). This unique combination of domains effectively allows CHIP to network chaperone complexes to the ubiquitin-proteasome and autophagosome-lysosome systems. WebJan 25, 2024 · CHIP binding to tau D421 , but not tau FL , promoted its ubiquitination, while binding to caspase-6 D179 mediated ubiquitin-independent inhibition. Given that caspase activity generates tau D421 … WebIt is possible for Medicaid beneficiaries to have one or more additional sources of coverage for health care services. Third Party Liability (TPL) refers to the legal obligation of third parties (for example, certain individuals, entities, insurers, or programs) to pay part or all of the expenditures for medical assistance furnished under a Medicaid state plan. in case you missed it newsletter section