Circrna binding protein

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August undefined, 2024

WebDec 7, 2024 · RNA-binding proteins (RBPs) are proteins that bind to double- or single-stranded RNA. Some RBPs contain well-established RNA-binding domains, including the RNA recognition motif (RRM) or the K-homology … WebCircRNAs can serve as protein sponges or decoys to influence their cellular functions, thereby regulating gene transcription, inhibiting cell cycle progression, promoting cardiac senescence, inducing apoptosis, and …

Circular RNA-protein interactions: functions, mechanisms, …

WebJun 29, 2024 · The majority of these proteins are known to bind RNAs and can be clustered based on the protein–protein interaction into two major groups, which are involved in RNA processing (e.g., hnRNPs)... WebJun 1, 2024 · Accumulating evidence indicates that circRNAs play significant roles in physiological and pathological processes by acting as microRNA (miRNA) and RNA-binding protein (RBP) sponges, regulators of transcription and splicing [3], and translators to produce polypeptides. sharon finegan

CSCD: a database for cancer-specific circular RNAs - PubMed

Web]. circRNA biogenesis can be mediated by RNA-binding proteins (RBPs) [ 16. ], intronic complementary sequences (ICSs) [ 17. ], or a lariat-driven back-splicing mechanism [ 18. ]. Currently, the profiles, functions, and mechanisms of how circRNAs exert effects on physiological and pathological states are emerging and remain under discussion. WebJun 22, 2024 · SCD-circRNA 2 is an independent risk factor for predicting prognosis of HCC patients. We also found that the biogenesis of SCD-circRNA 2 was promoted by RNA-binding protein 3 (RBM3). Strikingly, RBM3 expression is increased dramatically in HCC tissues, and the RBM3 level correlates positively with poor survival. Webdata sets of protein-circRNA binding sites, CRIP achieves higher prediction accuracy compared with both the traditional classi ers and state-of-the-art deep learning models. As far as we know, this is the rst predictor for circRNA-protein interactions using machine learning, which will assist in revealing important roles of circRNAs in gene ... population pittsburgh metro

CircRNA perspective: new strategies for RNA therapy

Frontiers DeCban: Prediction of circRNA-RBP Interaction

WebSep 24, 2024 · Circular RNAs (circRNAs) are a new type of long noncoding RNAs, and they are found in thousands of lives including plants, animals and humans [ 1 ]. Unlike linear RNAs, circRNAs have a circular closed loop structure, which do not contain 5′ caps and 3′ poly (A) structure. In addition, circRNAs’ expression is more stable. WebMar 31, 2024 · Luciferase reporter assay and RNA Binding Protein Immunoprecipitation (RIP) were used to demonstrate the underlying mechanism of circRNA_17725. ... Additionally, circRNA_17725-overexpressed macrophages alleviated arthritis and protected against joint injuries and bone destruction by inducing macrophage polarization towards … population pittsfield maWebAbstract. The widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene expression in highly diverged eukaryotes. Recent studies have shown that … sharon fine zebade

"WebAbnormal levels or dysregulation of miRNA or circRNA are linked to several cancerous pathologies, so that they are receiving a large attention as diagnostic and prognostic tools. ... consisting of the RNase III enzyme Drosha4, and a double-stranded RNA-binding protein Pasha/DGCR8. The resulting pre-miRNAs are approximately 70–100 nucleotides ... " - Circrna binding protein

Circrna binding protein

WebFeb 7, 2024 · Circular RNAs (circRNAs) are widely expressed in eukaryotes. The genome-wide interactions between circRNAs and RNA-binding proteins (RBPs) can be probed from cross-linking immunoprecipitation... WebTo begin to understand whether the PARP1 regulation of circRNA biogenesis occurs via cis base pairing of sequences and/or in trans by recruiting RNA-binding proteins (RBPs), we used a comprehensive analysis in determining the …

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WebJul 18, 2024 · Synthetic circRNAs and some endogenous circRNAs can encode proteins, raising the promise of circRNA as a platform for gene expression. In this study, we developed a systematic approach for... WebFeb 28, 2024 · Finally, we validated that CPSF6, as a circRNA-binding protein, interacted with and regulated its circular isoform circCPSF6 (hsa_circ_0000417), of which depletion also resulted in cell cycle ...

WebDec 14, 2024 · Abstract. Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to … WebFeb 10, 2024 · CircRNAs bind and sequester specific proteins to appropriate subcellular positions, and they participate in modulating certain protein-protein and protein-RNA …

WebJan 21, 2024 · Circular RNAs (circRNAs) represent an abundant and conserved entity of non-coding RNAs; however, the principles of biogenesis are currently not fully understood. Here, we identify two factors, splicing factor proline/glutamine rich (SFPQ) and non-POU domain-containing octamer-binding protein (NONO), to be enriched around circRNA loci. WebApr 14, 2024 · CircRNA, the latest research hotspot in the field of RNA, is a special non-coding RNA molecule, which is unable to encode proteins and bind polyribosomes. As a …

WebJan 17, 2024 · Circular RNAs (circRNAs) generally bind to RNA-binding proteins (RBPs) to play an important role in the regulation of autoimmune diseases. Thus, it is …

WebJul 15, 2024 · The binding of the Poly(A) binding protein (PABP) to this region can spatially interfere with its hairpin formation ability, thereby promoting the formation of EPHB4 circRNA. In addition, studies have shown that circEphB4 is up-regulated in glioma cells and promotes the proliferation and glycolysis of glioma cells, which is closely related to ... sharon finettoWebJul 15, 2024 · The binding of the Poly(A) binding protein (PABP) to this region can spatially interfere with its hairpin formation ability, thereby promoting the formation of … population place and spaceWebAug 4, 2024 · CircRNAs regulate gene expression by interacting with cellular regulators such as microRNAs and RNA binding proteins (RBPs) to regulate downstream gene expression. The accumulation of high-throughput RNA–protein interaction data revealed the interaction of RBPs with the coding and noncoding RNAs, including recently discovered … population planning cssWebMar 10, 2024 · When the protein level is high, circMbl production increases, while the production of its own mRNA decreases. Moreover, MBL protein is massively recruited by intronic binding sites retained in the circRNA. This adds a further level of negative control of circMbl on its own MBL protein coding linear transcript . sharonfingerman2 gmail.comWebApr 12, 2024 · QKI protein binds to the flanking sequence of circRNA-forming exons to promote circularization of circRNAs; thus, we postulated that QKI could identify QKI binding sites in the introns upstream ... sharon finley facebookWebApr 13, 2024 · A circRNA-miRNA-mRNA ceRNA network was constructed using TargetScan (5.0a) and Miranda (3.3a) to predict the target binding relationships of circRNA, miRNA, and mRNA in mesenchymal and cartilage tissues (Figure 4A). GO and KEGG enrichment analysis were performed on the RNAs in the ceRNA network. population planet earthWebFeb 15, 2024 · CircRNAs also form complexes with mRNA or chromatin upon the circRNA-protein complex. A circRNA may form a ternary complex with protein and mRNA to … population planning and control in india