http://atactk.readthedocs.io/en/latest/usage.html WebCTCF enrichment enabled identification of 11,000 chromatin domains with mean size of 258 kilobases. To our knowledge, this is the first report to use immunoprecipitated CTCF to determine putative topological domains in sheep immune cells. Furthermore, these data will empower phenotype-associated mutation discovery since most causal variants are ...
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WebOct 30, 2024 · CTCF is able to act as an insulator between genomic regions with different chromatin states, but how exactly this is achieved is not known. Here, we explore … WebJul 25, 2024 · A bedfile folder, providing the genomic coordinates of the first kilobase flanking OCCUPIED CTCF binding sites (CTCF.bed) Fu et al., 2008); A yaml-format makefile (example.yaml), representing the main input file required by epiPALEOMIX and containing path to BAM and BED files as well as indicating which analyses should be … can a wireless charger transfer data
CTCF knockout in zebrafish induces alterations in regulatory ... - Nature
WebJan 1, 2024 · We find that the chromatin insulating protein machinery, including CTCF, is suppressed and re-expressed, coincident with broad alterations in chromatin accessibility, during EMT/MET, and is lower in triple-negative breast cancer cell lines with EMT features. Through an analysis of chromatin accessibility using ATAC-seq, we identify that early ... Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of … See more CCCTC-Binding factor or CTCF was initially discovered as a negative regulator of the chicken c-myc gene. This protein was found to be binding to three regularly spaced repeats of the core sequence CCCTC and thus … See more The primary role of CTCF is thought to be in regulating the 3D structure of chromatin. CTCF binds together strands of DNA, thus forming chromatin … See more CTCF binds to the consensus sequence CCGCGNGGNGGCAG (in IUPAC notation). This sequence is defined by 11 zinc finger motifs … See more • Ohlsson R, Renkawitz R, Lobanenkov V (2001). "CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease". Trends Genet. 17 (9): 520–7. See more The binding of CTCF has been shown to have many effects, which are enumerated below. In each case, it is unknown if CTCF directly evokes the outcome or if it does so indirectly (in … See more CTCF binds to itself to form homodimers. CTCF has also been shown to interact with Y box binding protein 1. CTCF also co-localizes with See more • CCCTC-binding+factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook CTCF See more WebOct 11, 2024 · CTCF-mediated loops exhibit cell-type-specificity. a Venn diagram of CTCF-mediated loops identified from ChIA-PET experiments in GM12878, HeLa, and K562.b Heat map of CTCF-binding sites in … fishing alabama gulf coast