Ctgf sirna
WebOct 2, 2024 · S1P promotes YAP-mediated upregulation of cysteine-rich protein 61 and connective tissue growth factor (CTGF), and stimulates HCC cell proliferation. By using siRNA-mediated knockdown approaches, only CTGF was required for S1P-stimulated cell proliferation. ... D, Hepa1-6 cells were transfected with 50 nmol/L control siRNA (si-Ctrl) … WebDec 29, 2024 · Connective tissue growth factor (CTGF) is recognized as a critical regulator of myocardial extracellular matrix, including changes in the composition of collagen, an interstitial fibrosis marker . CTGF is a downstream autocrine/paracrine factor regulated by hormones including AngII, TGFβ, growth factors and cytokines. ... CTGF …
Ctgf sirna
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WebJul 31, 2015 · Connective tissue growth factor (CTGF) is a critical fibrogenic mediator of TGF-β1. Mammalian sirtuin 1 (Sirt1) is reported to attenuate renal fibrosis by inhibiting … WebMay 8, 2015 · Connective tissue growth factor (CTGF), which is also called CCN2, is a secreted matricellular protein. CTGF regulates various important cellular functions by interacting with multiple molecules in the …
WebCTGF expression measured by RT-qPCR and western blot was significantly down-regulated (~5 fold) by CTGF siRNA in MAS expressing HEK293 cells as well as in HCF cells, thus confirming its effective ... WebJun 6, 2012 · CTGF is a secreted matricellular protein with very complex biology. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, angiogenesis, myofibroblast activation, and extracellular matrix deposition and remodeling, which together lead to tissue remodeling and fibrosis. It has been reported in the …
WebBackground: Connective tissue growth factor (CTGF) is a highly profibrogenic molecule implicated in hepatic fibrogenesis. Small interfering RNA (siRNA) is an effective tool to … WebMar 10, 2024 · Connective tissue growth factor (CTGF), also known as CCN2, is a member of the CCN protein family of secreted proteins with roles in diverse biological processes. ... we transfected Glut1 siRNA to ...
WebJul 1, 2011 · Transgenic mice that over-express connective tissue growth factor (CTGF) in fibroblasts under the control of an enhancer/promoter element of the Col1a2 gene (Col1a2-CTGF) ... and were transfected with Sparc siRNA or Ctgf siRNA. Real-time quantitative RT-PCR and Western blotting were used to examine the transcription and …
WebThe purpose of this study is to investigate the involvement of CTGF in tumor progression and prognosis of human nasopharyngeal carcinoma (NPC). CTGF expression levels … fitted hula hoopWebOverexpression of CTGF enhances resistance to 5-FU-promoting cell death. To examine the potential role of CTGF on the regulation of chemoresistance to 5-FU, we first confirmed that the pCDNA3.1-CTGF vector and CTGF small interfering RNA (CTGF-siRNA) were overexpressing and interfering with the protein and mRNA of CTGF in HT-29 and SW620 … can i eat chili if i have high cholesterolWebConnective tissue growth factor (CTGF), also termed fisp12, β IG-M2, and IGF-BP8, is a secreted cysteine-rich growth factor that belongs to the CCN (cyr61, CTGF, nov) family. It was first isolated in 1991 from serum-stimulated NIH3T3 cells and named fisp12 (fibroblast-inducible secreted protein-12). The term ‘connective tissue growth factor ... can i eat chips after wisdom teeth removalWebDec 3, 2024 · To further confirm the involvement of Src kinase in TGF-β1-mediated CTGF induction, we employed siRNA-mediated knockdown of Src protein, and found that siRNA-treated cells showed 60–70% ... can i eat chocolate after wisdom teethWebSep 13, 2024 · After CTGF siRNA interference, the expression of intracellular CTGF mRNA was significantly lower than that in normal 16HBE cells caused by silica particles. The levels of IL-8, TNF-α, IL-6 and IL-17A secreted from CTGF siRNA-transfected cells also significantly decreased when compared with normal 16HBE cells with exposure to silica … can i eat chips before bedWebJan 8, 2015 · These results suggest that TGF-β 1-siRNA delivery with NPs is a promising therapeutic approach for the inhibition of PF. Liposome-based NPs have been reported … can i eat chicken with gerdWebApr 7, 2024 · TGFβ and CTGF promote fibrosis by NOTCH signaling pathway activation. Therefore, TGFβ1 and CTGF were used to activate NOTCH signaling in vitro. First, human healthy meniscus cells were treated with TGFβ1, NOTCH3 siRNA (or HEYL siRNA), or TGFβ1+NOTCH3 siRNA (or HEYL siRNA). The COL1A1 RNA levels were detected by … fitted inc