Web21 de jul. de 2024 · 2024年,Howard Y. Chang团队再次在Molecular Cell杂志发表文章证明了外源合成的环状RNA确实可以诱导自身免疫效应相关的通路,他们发现细胞通过识别 … WebWelcome to Howard Chang's lab homepage. Our lab is part of the Center for Personal Dynamic Regulomes , the Program in Epithelial Biology and Cancer Biology , and …
QnAs with Howard Y. Chang - ResearchGate
WebHoward CHANG Cited by 74,898 of Stanford University, CA (SU) Read 543 publications Contact Howard CHANG We first sought to uncover principles behind circRNA vector topology that are necessary for strong translation. We began by synthesizing circRNAs with a coxsackievirus B3 (CVB3) IRES (denoted iCVB3) downstream, or 3′, of the reporter NanoLuc gene, maintaining the reading frame through the residual … Ver mais Synthesis of circRNAs via intron-assisted splicing and RNaseR digestion has been previously described4, but rapid creation of different circRNA … Ver mais 5′ and 3′ UTRs in mRNAs can recruit RNA-binding proteins (RBPs) that enable strong translation as well as aspects of post-transcriptional … Ver mais We previously showed that circRNAs can trigger immune responses in vivo that can be avoided by modifying circRNAs with m6A4,11. However, the effect of m6A incorporation on … Ver mais Viral IRESs are diverse and highly structured RNA regions found primarily in viral 5′ UTRs that promote cap-independent … Ver mais c sharp floor
Circular Rnas And Their Use In Immunomodulation Chang; Howard Y…
Web26 de nov. de 2024 · Yigang Chen, Lantian Yao, Yun Tang, Jhih-Hua Jhong, Jingting Wan, Jingyue Chang, Shidong Cui, Yijun Luo, Xiaoxuan Cai, Wenshuo Li, Qi Chen, Hsi-Yuan Huang, Zhuo Wang, Weiming Chen, Tzu-Hao Chang, Fengxiang Wei, Tzong-Yi Lee, Hsien-Da Huang, CircNet 2.0: an updated database for exploring circular RNA regulatory … Web3 de out. de 2024 · Circular RNAs (circRNAs) are prevalent in eukaryotic cells and viral genomes. Mammalian cells possess innate immunity to detect foreign circRNAs, but the … WebCircular RNAs (circRNAs) are stable and prevalent RNAs in eukaryotic cells that arise from back-splicing. Synthetic circRNAs and some endogenous circRNAs can encode … ea.com/uable-to-connect