Web21 jun. 2024 · Accumulation of mutant huntingtin (mHtt) during this disease may evoke mitochondrial dysfunction. Here, we review recent findings to support this hypothesis that mHtt could cause mitochondrial defects. In addition, by focusing normal huntingtin functions in neurons, we purpose mitochondria and Huntingtin association in normal … WebThis way, mutant huntingtin could interfere with proteins that regulate transcription, apoptosis, tumor suppression or axonal transport (Bae et al., 2005; Busch et al., 2003; Charrin et al., 2005; Gauthier et al., 2004 , Hickey & Chesselet, 2003). Lastly, one other hypothesis states that mutant huntingtin may interfere in neuron-neuron interaction.
The Clash of Civilizations Thesis: A Critical Appraisal
Huntington argues that the trends of global conflict after the end of the Cold War are increasingly appearing at these civilizational divisions. Wars such as those following the break up of Yugoslavia, in Chechnya, and between India and Pakistan were cited as evidence of inter-civilizational conflict. He also argues … Meer weergeven The Clash of Civilizations is a thesis that people's cultural and religious identities will be the primary source of conflict in the post–Cold War world. The American political scientist Samuel P. Huntington argued that … Meer weergeven The book has been criticized by various academic writers, who have empirically, historically, logically, or ideologically challenged its claims (Fox, 2005; Mungiu Pippidi & … Meer weergeven • Civilizations portal • Balkanization • Civilizing mission • Cold War II Meer weergeven Huntington divided the world into the "major civilizations" in his thesis as such: • Western civilization, comprising the United … Meer weergeven Japan, China and the Four Asian Tigers have modernized in many respects while maintaining traditional or authoritarian societies … Meer weergeven • Eurasianism, a Russian geopolitical concept based on the civilization of Eurasia • Intermediate Region • Islamo-Christian Civilization Meer weergeven • Ankerl, Guy (2000). Global communication without universal civilization. INU societal research. Vol. 1: Coexisting contemporary civilizations: Arabo-Muslim, Bharati, Chinese, and Western. Geneva: INU Press. ISBN 978-2-88155-004-1 Meer weergeven Web15 mrt. 2004 · In 1993, the gene mutation for Huntington disease (HD) was identified and testing became possible with a reliability of >99%, without the need for co‐operation of relatives. In 1997, a systematic information program offered the mutation retest to individuals who had earlier received a linkage test result for HD, which has a residual uncertainty of … hercules chromo
Ziekte van Huntington Erfelijkheid.nl
WebBackground: Huntington's disease (HD) is a devastating heredoneurodegenerative disorder associated with a wide variety of neurological and psychiatric symptoms caused by an expanded CAG repeat in the HTT gene. The expansion mutation in HTT is dominantly transmitted and codes for a protein named huntingtin (htt). WebThe neurodevelopmental hypothesis of HD (and other degenerative disorders) [ 3] posits that disease-causing gene affects development of a specific region or specific brain circuit. These cells are abnormal in their growth; however they are compensated for early in life ( … Web6 sep. 2009 · It is my hypothesis that the fundamental source of conflict in this new world will not be primarily ideological or primarily economic. The great divisions among humankind and the dominating source of conflict will be cultural. hercules christmas episode