WitrynaThe immunoproteasome and thymoproteasome: functions, evolution and human disease Nat Immunol. 2024 Sep;19(9):923-931. doi: 10.1038/s41590-018-0186-z. ... the immunoproteasome and the thymoproteasome. In this Review, we describe various aspects of these immunity-dedicated proteasomes, from their discovery to recent … Witryna25 maj 2016 · The endoplasmic reticulum (ER) is involved in calcium homeostasis, protein folding and lipid biosynthesis. Perturbations in its normal functions lead to a condition called endoplasmic reticulum stress (ERS). This can be triggered by many physiopathological conditions such as alcoholic steatohepatitis, insulin resistance or …
Proteasome function shapes innate and adaptive immune responses
Witryna25 cze 2012 · Functions of immunoproteasomes, other than generating peptides for antigen presentation, are emerging from studies in immunoproteasome-deficient mice, and are complemented by recently described ... Witryna13 kwi 2024 · The “compensatory” upregulation of both the standard and immunoproteasome, paired with an enhanced ubiquitin and aggresome abundance in UCH-L1 I93M podocytes suggest that non-functional UCH-L1 ... can scottish bank notes be used in england
The immunoproteasome and thymoproteasome: …
Witryna30 lis 2024 · Proteasomes are responsible for intracellular proteolysis and play an important role in cellular protein homeostasis. Cells of the immune system assemble a … Witryna22 cze 2024 · Various immunoproteasome inhibitors have shown promising preliminary results in pre-clinical studies, and one inhibitor is currently being investigated in … WitrynaWe thank Andrew Wong and Javier Lopez (UC Davis) for help with flow cytometry and Jim Trimmer (UC Davis) for help with microscopy. The immunoproteasome inhibitors were kindly provided by Kyung-Bo Kim (University of Kentucky, Lexington, KY). No conflicts of interests are associated with the article. flannel mouth definition