WebIntroduction. The anticancer drug cisplatin (CDDP; cis-[PtCl 2 (NH 3) 2]; Fig. 1) forms several structurally distinct DNA adducts, including 1,2-GG intrastrand cross-links and 1,2-GC interstrand cross-links (IXLs), which are considered ultimately responsible for its biological activity [1–3].Protein recognition of the ensuing conformational distortions is an … WebCrosslinking of DNA can be caused by chromium metabolites. The concentrations of chromium bound to DNA are related to the levels and stabilities of the chromium (V) …

Inter- and intrastrand DNA crosslinks by 2-fluoro-substituted ...

WebMar 1, 1997 · Molecular dynamic simulations provided a structural explanation for this difference, in that the monofunctionally bound intermediates of mechlorethamine and phosphoramide mustard assumed thermodynamically stable conformations with the second arm in a position appropriate for intrastrand crosslink formation, while the … WebOct 19, 2005 · R,R-DEB treated DNA contained mostly 1,3-interstrand bis-N7G-BD, along with smaller amounts of 1,2-interstrand and 1,2-intrastrand adducts. The effects of … teaspoons and tablespoons conversion chart

The evolving role of DNA inter-strand crosslinks in chemotherapy

Web(intrastrand), between the two complementary strands of DNA (interstrand), or between a base on DNA and a reactive group on a protein (DNA-protein). The available evidence … WebTumour cells isolated from 50 ovarian cancer patients were treated ex vivo with 100 μ M cisplatin for 1 h and crosslink formation and repair (unhooking) measured. No significant difference in the peak level of crosslinking in tumour cells was observed between patients who were either newly diagnosed or previously treated with platinum-based therapy, or … WebMinistry of Education of the People's Republic of China; Tianjin University of Science and Technology; Natural Science Foundation of Shandong Province spanish muralist crossword