Photoactivated chemotherapy
WebDec 1, 2024 · Abstract. Following the serendipitous discovery of the anticancer drug, cisplatin, numerous platinum (II) complexes have been synthesized and some of them, such as carboplatin, oxaliplatin, nedaplatin, heptaplatin and lobaplatin, have been clinically approved either locally or worldwide. Since these drugs are structurally related to cisplatin ... WebOct 10, 2024 · Photoactivated chemotherapy (PACT) has emerged as a promising strategy to selectively target cancer cells by using light irradiation to generate cytotoxic complexes in situ through a mechanism ...
Photoactivated chemotherapy
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WebNov 2, 2024 · I will mainly introduce (1) a photoactivated prodrug system based on controllable intracellular polymerization. This method successfully induces programmed cell death such as apoptosis and necrosis by in situ synthesis of high molecular polymers with controllable structures in tumor cells, and inhibits cell proliferation by interfering with the ... WebSep 15, 2024 · Photodynamic therapy (PDT) is a spatiotemporally controllable, powerful approach in combating cancers but suffers from low activity under hypoxia, whereas …
WebSep 21, 2016 · My project involved design and synthesis of ruthenium and dirhodium based anticancer metallodrugs for their potential applications in Photodynamic Therapy (PDT) and Photoactivated Chemotherapy (PACT). WebThe development of photoactivated chemotherapy based on photoresponsive polymers that can be activated by light in the “therapeutic window” would enable new approaches for basic research and allow for anticancer phototherapy in hypoxic conditions. This work synthesizes a novel Ru-containing block copolymer for photoactivated chemotherapy in ...
WebPhotoactivation localization microscopy (PALM) is an imaging technique that is methodologically similar to STORM and uses a repetitive process to excite the … WebThe Ru(II) moieties in PolyPt/Ru can generate 1 O 2 for photodynamic therapy (PDT) and release anticancer Ru(II) complexes for photoactivated chemotherapy (PACT). Additionally, we used the hydrophilic and biocompatible PEG block because it can prolong blood circulation and suppress nonspecific adsorption of proteins that deactivate metallodrugs.
WebSep 9, 2024 · Moreover, metal-based nanoparticles, photoactivated chemotherapy, catalytic active compounds, or complexes with bioactive ligands may lead to new therapeutics and improved outcomes for cancer ...
WebApr 26, 2024 · In addition, photoactive chemotherapy (PACT) has the potential to overcome the limitations imposed by hypoxia. In PACT, metal complexes can be photoactivated in a controlled manner to produce ... inal law officeWebNov 6, 2024 · Platinum-based anticancer drugs are a class of widely used agents in clinical cancer treatment. However, their efficacy was greatly limited by their severe side effects … inal day of forestsWebNational Center for Biotechnology Information inch kochel ays sere 25WebCombination of chemotherapy and gene therapy provides an effective strategy for cancer treatment. However, the lack of suitable codelivery systems with efficient endo/lysosomal … inch kochel ays sere 36WebPhotoactivation definition, the activation or control of a chemical, chemical reaction, or organism by light, as the activation of chlorophyll by sunlight during photosynthesis. See … inch kochel ays sere 29WebAug 14, 2024 · Photoactivated chemotherapy of the polymer micelles demonstrates efficient tumor growth inhibition. In addition, the polymer micelles do not cause any toxic side effects to mice during the treatment, demonstrating good biocompatibility of the system to the blood and healthy tissues. The novel red-light-responsive Ru-containing … inal herniaWebThe fields of phototherapy and of inorganic chemotherapy both have long histories. Inorganic photoactivated chemotherapy (PACT) offers both temporal and spatial control over drug activation and has remarkable potential for the treatment of cancer.Following photoexcitation, a number of different decay pathways (both photophysical and … inch kochel ays sere 39