WebSep 23, 2024 · A NB murine model has been established by the targeted expression of the human MYCN oncogene in neuroectodermal cells under the control of rat tyrosine hydroxylase promoter (TH-MYCN) . Büchel et al. further investigated the effect of Gal-1 on tumor formation, angiogenesis, and tumor–host interaction by cross-breeding Gal-1 −/− … WebApr 4, 2024 · Changes in tumor volume in the TH-ALK F1174L /TH-MYCN mice were quantified using MRI on a 7T horizontal bore MicroImaging system (Bruker Instruments) using a 3 cm birdcage coil. Anatomic T2-weighted coronal images were acquired through the mouse abdomen, from which tumor volumes were determined using segmentation …
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WebAug 16, 2004 · TH-MYCN mice developed large, paravertebral thoracic or abdominal tumors at a median of 6.5 (±0.27) weeks in 100% of homozygotes and by 13 (±2.67) weeks in 33% of hemizygotes . These tumors were indistinguishable from human neuroblastoma tissue based on histologic, immunohistochemical, and cytogenetic studies . To better ... WebMoreover, we performed quantitative proteomics and identified 150 differentially expressed proteins after tozasertib treatment in the Th-MYCN mouse model. The functional and network-based enrichment revealed that tozasertib alters metabolic processes and identified a mitochondrial flavoenzyme in fatty acid β-oxidation, ACADM, which is … morley expression pedal
Tumor development, growth characteristics and spectrum of
WebWe used a transgenic TH-MYCN (tyrosine hydroxylase-MYCN) mouse model, genetically engineered to overexpress MYCN under the control of a rat TH-promoter. The overexpression of MYCN occurred in neural crest cells, which resulted in tumors closely resembling human neuroblastoma in terms of tumor localization and histology, genomic … WebJan 27, 2024 · The neuroblast hyperplasia in the ganglia from Th-MYCN did not express differentiation markers, such as beta-III-tubulin or tyrosine hydroxylase, differing from nearby neuronal cells . Althoff et al. generated a transgenic mice, termed LSL-MYCN;Dbh-iCre, with Cre-conditional induction of MYCN in Dbh-expressing cells. These mice form tumors ... WebMar 31, 2015 · Hyperplasia in TH-MYCN mice is mainly composed of undifferentiated progenitor cells . To confirm that the Phox2B + neuronal progenitors were in an undifferentiated state, the tissue sections were immunostained for markers of mature sympathetic neurons. Fig. 3 demonstrates the morphology of mature sympathetic … morley experiment